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Growth, growth hormone and the somatomedins: a historical perspective and current concepts

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Following multiple doses, mean insulin-like growth factor (IGF-1) levels remained above baseline for up to 28 days

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy