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Among the patients who took lorcaserin and achieved a 5% or more weight loss after 1 year, more patients who continued taking lorcaserin during the second year (67.9%) were able to maintain their weight loss compared to those who received the placebo during the second year (50.3%)

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Blood clots and severe allergic reactions have also been reported

Seek prompt medical advice if you experience: Severe or rapidly worsening joint pain that significantly impairs function or mobility A hot, swollen, very painful joint with fever this could indicate septic arthritis requiring SAME-DAY emergency hospital assessment Symptoms of severe allergic reaction after B12 injection (breathing difficulty, facial/tongue swelling, widespread hives, dizziness/collapse) call 999 immediately Systemic symptoms such as unexplained weight loss, night sweats, or profound fatigue Neurological symptoms including weakness, numbness, balance problems, or cognitive changes Symptoms affecting multiple joints simultaneously, particularly if symmetrical (both hands, both knees) Morning stiffness lasting more than 30 minutes , which may suggest inflammatory arthritis Your GP will conduct a thorough clinical assessment, including detailed history-taking and physical examination

Future large-scale, multicenter trials with standardized protocols are essential to validate these findings and facilitate the integration of natural products into mainstream AD treatment frameworks