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Jacamo R, Chen Y, Wang Z, Ma W, Zhang M, Battula VL, Schober WD, Davis RE, Konopleva M, Andreeff M

While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress

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This proposal was based in part on the finding that [GSH]:[GSSG] in the secretory pathway and in microsomal vesicles is similar to the ratio found in redox buffers that are effective for the oxidative folding of proteins in vitro that is, between 1:1 and 3:1 (Bass et al , 2004