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Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, transient elevations in serum amylase, and opioid-induced esophageal dysfunction (OIED)

10.1186/s13073-023-01179-2 72 KarakoseE.WangX.WangP.CarcamoS.DemirciogluD.LambertiniL.et al (2024)

Compared to ulcerative colitis, in which the AMP system seems to be adequately induced, colonic Crohn's disease is characterized by low HBD1, regulated by peroxisome proliferator-activated receptor gamma (PPAR), and a compromised induction of HBD2 and HBD3 (307, 308)