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Jo SJ, Paik SH, Choi JW, et al

Each method has unique bioavailability and effectiveness profiles designed to meet specific treatment needs

Mlcek J, Jurikova T, Skrovankova S, Sochor J

To compare it to the human body, mitochondria are like the heart, continually pumping out ATP instead of blood

To ask how -KG insufficiency depletes the cytosolic NADPH pool, we first confirmed that cytosolic NADPH-producing enzymes ME1 and IDH1 are essential for cell survival during energy stress, as previously reported 26,31 , because knockdown of either gene sensitized Huh7 and H1299 cells to glucose starvation (Supplementary Fig