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The pathogenesis of GBM The pathogenesis of GBM includes gene mutations, signaling pathway dysregulation, epigenetic modifications, and tumor microenvironment (TME), which collectively drive tumor initiation, progression, invasion, and treatment resistance [13, 14]

Journal of Clinical Oncology 42(16), 2024

doi: 10.1002/mds.26417 218 LehricySSharmanMASantosCLDPaquinRGalleaC

However, the erythropoietic activity of IGF-1 has been recognized since 1985.124 Despite of this evidence, the potential role of the IGF-1 in the development of anemia within the context of CKD remains insufficiently explored