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54 Although short-term administration of adropin may fail to exert a protective effect on cardiac function in obese animals

Inhibition of phosphodiesterase (PDE) also causes increase cAMP

While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations

Statements Author contributions MC: Data curation, Funding acquisition, Investigation, Methodology, Writing original draft