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Methods This international panel of multidisciplinary experts in the management and/or study of CCA, including physicians and clinical researchers (oncologists, surgeons, hepatologists, gastroenterologists and pathologists), basic and translational scientists, and patient representatives, is affiliated with the European Network for the Study of Cholangiocarcinoma (ENS-CCA) and is part of the European COST Actions Euro-Cholangio-Net (20192023) and Precision-BTC-Network (20232027)

WT mice were unilaterally injected with AAV- hSyn - SNCA or - GPX4 into the substantia nigra as described above to obtain strains overexpress human -synuclein, GPX4, or both

We hypothesize that inhibiting intracellular glutamine transport via ASCT2, such as with V-9302, may be a more effective strategy for targeting glutamine metabolism in PIK3CA -mutant cancer cells than targeting downstream enzymatic activities, such as GLS1 or glutamine synthetase

Warnings Pregnancy This medicine is not recommended for use in pregnant women unless necessary

Hernndez-Fonseca JP, Rincn J, Pedreaez A, Viera N, Arcaya JL, Carrizo E