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Apoptosis, or programmed cell death, plays a critical role in the progression of dementia, particularly in Alzheimers disease and other neurodegenerative disorders where excessive neuronal loss accelerates cognitive decline 43

A cross-sectional study with over 40,000 participants discovered that increased levels of physical activity led to an augmentation of the thickness in the plexiform layer within the retina (104)

While Metformin does have some side effects, such as abdominal pain and diarrhea, these are typically mild and go away with time

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however the purpose of this review is to evaluate, and give an overview of, the most common types of treatment (radiation, chemotherapy and surgery) and specifically tissue engineering approaches to mediate the damage of these treatments inflicted upon the TME