Koeglsperger et al., 2023)
Ressmeyer AR, Mayo JC, Zelosko V, et al
BRAF V600E co-occurs with a similar set of alterations in pediatric and adult tumors, and both patient groups can benefit from BRAF-targeted therapy ( In non-CNS solid cancers, BRAF V600E is frequently detected in malignant melanoma, hairy cell leukemia, colorectal carcinoma, and papillary thyroid carcinoma, as well as ovarian and lung tumors ( V600 mutation ( V600E -mutated melanoma were more likely to have CNS involvement than those with BRAF wild-type melanoma ( V600E expression cooperates with Pten tumor suppressor loss to generate metastatic melanoma without CNS involvement ( V600E in Cdkn2a Null mice generates melanomas without metastasis, but AKT1 activation promotes development of CNS metastases in this model ( In conclusion, BRAF V600E expression is a driver mutation of CNS tumors that occur in various neuroanatomic locations and exhibit a wide range of age at presentation
En base a estas observaciones, la HFR parece ser una tcnica especialmente til para pacientes con elevada comorbilidad, incluyendo aquellos con fragilidad, desnutricin o enfermedad cardiovascular
This combination strategy holds potential promise for reducing cisplatin dosage and associated toxicity, which provides insights into cannabinoids role as adjuvant agents in cancer treatment
