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Activation of these receptors modulates cytokine secretion, epithelial permeability, and neutrophil recruitment, suggesting a direct pathway by which dysbiotic metabolic profiles influence local immunity

Briefly, 50 l of a 26% pluronic F-127 gel (Sigma-Aldrich, P2443) (w/w, dissolved in H2O) were solidified at the bottom of a 35 mm plate and 40-45 worms were placed on top

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However, luteolin's potential benefits in AD are primarily linked to the modulation of amyloid- accumulation and tau hyperphosphorylation, whereas in PD its effects are more closely associated with the inhibition of -synuclein aggregation, protection of dopaminergic neurons, and improvement of mitochondrial function, particularly at the level of complex I