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Clment K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnres P, Lebouc Y, Froguel P, Guy-Grand B

The sensitivity analysis of breastfeeding pattern, in which the number of feeds and the breast milk volume per feed were varied, showed no major impact on the predicted concentration-time profile, the maximum concentration (C MAX ), or area under the concentration-time curve (AUC) in infants for both primaquine and carboxyprimaquine (see Supplementary Figs

concluded that in a rat supraspinatus overuse tendinopathy model, exogenous melatonin administration (10 mg/kg twice daily) significantly reduced oxidative stress, iNOS and VEGF levels, improving the oxidant-antioxidant balance (lower OSI, TOS, and VEGF) and attenuating inflammation comparably to corticosteroid therapy (Kocadal et al., 2019)

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34, 35, 36 These observations would indicate the essential involvement of inflammatory responses in the development of liver damages caused by APAP