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2022 Mar 25;8(1):e003

Mitochondrial metabolism serves a dual role in the cardiovascular system: it is the primary energy source for cardiomyocytes and a central integrator of overall cardiac health, and its dysfunction is a key driver of disease pathogenesis [128]

First, the acceleration of early improvement is clinically meaningful for patients with time-sensitive goals

This EPO-R/CD131 selectivity allows for neuroprotection and tissue repair without the thrombotic risks of erythropoietin

As Sherman and colleagues note, RWE can leverage data already collected during routine care, reducing both the time and expense required to generate evidence compared with initiating new trials