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doi:10.1002/clc.22422 Hariri E, Kassis N, Iskandar JP, et al

Exerciseinduced oxidative stress: cellular mechanisms and impact on muscle force production

proposed that a the phospholipid/Ca++ dependent brain pkc participated in the expression of neuroplasticity and demonstrated this effect using the phorbol acetate TPA to enhance the action of pkc to maintain LTP in rat hipoccampal neurons (Routtenberg et al., 1986), in effect, producing a a long-lasting potentiation of synaptic activation (Nogus, 1997)