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However, Cheng et al

Intramyocardial transplantation of these IGF-1-overexpressing cardiac stem cells in the infarcted area also preserves stem cells in the damaged region and increases myocardial regeneration without affecting its differentiation into cardiomyocytes, smooth muscle, or endothelial cells (Jackson et al., 2015)

The PI3K/AKT/mTOR signaling pathway is a prevalent mechanism of cancer activation, contributing to tumor cell proliferation and various malignant biological processes, as well as influencing the expression of genes related to cancer cell proliferation and apoptosis