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Nevertheless, the preclinical animal model gives proof-of-concept and is pivotal for designing clinical trials and successfully generating a wealth of data in drug discovery

PGC-1: peroxisome proliferator-activated receptor- coactivator-1

In another groups report, ISA inhibits the secretion of pro-inflammatory cytokines from microglial cells exposed to LPS through activating Akt/Nrf2/HO-1 pathway and suppressing NF-B translocation (He et al., 2022)