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Stress: One common trigger for IC symptoms is stress

Acknowledgements The authors have no funding sources to declare

In preclinical mouse models, we and others showed that increased hepatic ammonia due to the loss of GLUL or increased ammonia import via SLC4A11 can promote HCC development ( 7 , 8 )

76 Human hepatocyte models are a next logical step, and thus more investigations need to be carried out before either serotonin or SFN can be realistically considered on the therapeutic level