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Peripheral administration and AAV-mediated liver expression of brain-penetrant PGRN biologics have been shown to rescue phenotypes of Grn / mice and Grn / Tmem106b / DKO mice, respectively [197, 210]

Simultaneously, prolactin can alter the expression of lipidogenesis genes in subcutaneous white adipose tissue and exacerbate glucose intolerance induced by a high-fat diet ( 4.3 Insulin resistance and glucose metabolic dysregulation Clinical, epidemiological, and experimental studies have consistently shown that hyperprolactinemia is strongly associated with glucose metabolism disorders that primarily manifest as insulin resistance and impaired glucose tolerance

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Prompt medical evaluation is important if symptoms include: Difficulty breathing at rest Inability to lie flat comfortably Chest pain Rapid or irregular heartbeat Swelling in one leg Symptoms worsening progressively over days or weeks These findings may indicate serious cardiac, pulmonary, or vascular conditions beyond Lyme disease

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