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For instance, post-hoc analyses of pre- and post-treatment biopsy samples from Ewing sarcoma patients treated with either IGF-1R mAb or a combination of cixutumumab and the mTOR inhibitor temsirolimus revealed that median PFS and OS was better in phospho-IGF-1R-negative patients

DNA nanostructures have demonstrated promising potential in translational medicine, specifically in novel applications like targeted drug delivery, biosensing, molecular imaging, and nucleic acid therapeutics 131

While targeted drug delivery methods have shown promise in treating TNBC, off-target effects can lead to adverse side effects and complications that may become life-threatening (158)