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10.1105/tpc.000596 75 YadavS

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Stability of pure metabolites during extraction process in absence of biological sample was monitored by UV-VIS spectroscopy

Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported

In one study carried out on 2898 participants who lived in an area with factory-released dioxin, 425 diabetes (14.7%) subjects were identified, and a higher serum dioxin level is a risk factor for developing diabetes mellitus (Huang et al