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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

Furthermore, these polysaccharides help maintain the integrity of the intestinal barrier ( Lactobacillus spp

albicans (Wang et al., 2022)

References 1 Al OjaimiM.SalahA.El-HattabA

82,83 As a classical effector of RNAi, siRNA induces gene silencing by blocking mRNA translation