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Conjugation reactions involving maleimides and phosphorothioate oligonucleotides

JAK-2 enhances the phosphorylation of STAT-3, leading to astroglial activation and exaggeration of inflammatory response in neurological disorders (Hou et al

Preclinical research has shown that inhibiting DDR proteins like PARP enhances the anti-tumor immune response facilitated by PD-L1 inhibition through T cell-mediated effects [95, 96]

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However, singleagent immunotherapies have limitations, such as limited efficacy and drug resistance