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Science 323:12051208 Vance C, Rogelj B, Hortobgyi T et al (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

De novo synthesis by GTP cyclohydrolase I BH4 is formed de novo from GTP, via a sequence of enzymatic steps carried out by GTP cyclohydrolase I (GTPCH), 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase (SR) [15]