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Immune System Diseases-Rheumatology, Oncology Departament and Internal Medicine (CIBEREHD), Prncipe de Asturias University Hospital, Alcal de Henares, Spain

Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans

Furthermore, a metabolic profiling study of 200 ME/CFS patients identified diminished serum amino acids essential for oxidative metabolism, alongside elevated expression of pyruvate dehydrogenase kinases (PDKs) in PBMCs, which inhibited pyruvate dehydrogenase (PDH)