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Araujo et al

SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105

Quercetin significantly reduces inflammatory factors (TNF-, IL-1) and oxidative stress markers (MDA) while upregulating antioxidant enzymes (SOD, GSH) in DN models by inhibiting PI3K/PKB, AMPK-P38 MAPK, and TGF-1/Smad pathways (Yu et al., 2023)