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Gene network analyses identify co-regulated transcription factors and BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes

Laut der bersichtsarbeit Growth hormone secretagogues: history, mechanism of action, and clinical development" (Ishida et al., 2020) wurde Ipamorelin ursprnglich von Novo Nordisk (Dnemark) entwickelt und als Ausgangspunkt fr weitere klinische GH-Sekretagoga wie Tabimorelin genutzt

doi: 10.1371/journal.pone.0011511

doi: 10.1038/s41568-022-00459-0

Factors with the strongest association with HCC development were liver cirrhosis (hazard ratio [HR]/95% confidence interval: 3.00/1.55-5.81, P =0.001), followed by male gender (: 2.98/1.51-5.90, P =0.02), BMI (HR: 1.11, CI: 1.041.18, P =0.002) and age (HR: 1.06, CI: 1.041.09, P 0.74