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Cost considerations may represent significant barriers to access, as these peptides are typically not covered by health insurance and may represent substantial out-of-pocket expenses for patients

The application of Pt nanozymes against organ-specific toxicity requires precise targeting to the injured organ (e.g., liver, kidney) to avoid unintended redistribution

GGC also upregulated the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-, IL-6, and IL-1) and attenuated the changes in metalloproteinase activity in oligomeric A 40 -treated astrocytes

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Some sensitive patients may benefit from microdosing (below 0.25 mg) or customized compounded formulations to improve tolerance