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In this regard, different studies have suggested a positive effect of metformin on HDL functionality

This contrasts with findings by Wang et al

Sieglinde Klaus References Raun K., et al

Khavinson V.K., et al

Issues such as low aqueous solubility, batch-to-batch variability of botanical extracts, and the absence of robust pharmacokinetic and pharmacodynamic data in humans continue to limit their direct comparability with synthetic agents [37,38,39]