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UV exposure induces the production of ROS, which subsequently activate the NF-B and MAPK signaling pathways, leading to increased transcription of pro-inflammatory cytokines (IL-1, TNF-, IL-6 and COX-2) and MMP-1, both of which contribute to inflammation and collagen degradation

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915,916 Investigations have also demonstrated that muscle atrophy caused by iron overload is connected to the ROS-mediated activation of the ubiquitin-proteasome system

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