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Benefit statements have not been evaluated by the FDA.

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This patient's severe hypercholesterolemia indicates massive cholesterol accumulation rather than impaired synthesis, making decreased HMG-CoA reductase activity unlikely

As ATP6AP1 KO cells display a higher glucose uptake and rate of glycolysis, cytosolic pH alkalinization might promote this phenomenon as glycolytic enzymes generally perform most efficiently in a slightly alkaline environment (around pH 7.58.0) 68,69

Cell viability assay A549 cells, HepG2 cells, or NIH-3T3 cells were incubated with different concentrations of NPs for 24 h, or with nanoparticles at the defined concentration (equivalent to 10 M of Ce6) for the indicated time periods