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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Peptide sequence, molecular size, terminal modifications, pH sensitivity, oxidation-prone residues, concentration, and solvent all affect stability

Its worth noting that the cocrystal structure of compound 16, when bound to SjGST, clearly shows that its binding mode considerably overlaps with IBZGSH at the H-site, thus significantly differing from known GSH-like compounds

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The deficiency of B12 is mostly due to inherited defects which result in malabsorption or the impaired transport of the vitamin within the body