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However, the majority of successful vaccines to date are designed to induce humoral immunity against pathogens that are extracellular and/or mediate disease through toxins ( While BCG confers consistent reliable protection against TB meningitis and disseminated disease when administered at birth ( After decades of neglect, TB vaccine development gained renewed momentum in the 2000s and there are currently 16 vaccine candidates in the clinical pipeline including live attenuated vaccines, inactivated whole-cell mycobacteria, subunit viral vectored vaccines and adjuvanted subunit vaccines ( Mycobacterium indicus pranii (MIP) and Mycobacterium vaccae