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[2] Cell Line:pBabe-MCF10A and CD8-IGF-IR-MCF10A acini Concentration:1 M Incubation Time:Every four days for 12 days Result:Blocked acinar proliferation

Using three cancer models, we show that induction of senescence by either palbociclib or cisplatin makes tumours sensitive to GPX4 inhibitors at concentrations at which toxicities are spared

The first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxia

These systems allow for more versatile activation mechanisms Fig

Pro-fusion proteins, such as MFN1, MFN2, and OPA1, are significantly downregulated, while pro-fission proteins DRP1 and FIS1 are upregulated [56]