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A major advance came in 1913, when Santiago Ramn y Cajal, using the gold-sublimate method, described two key astrocyte subtypes: Protoplasmic astrocytes, found in grey matter and marked by fine, elaborate processes, and fibrous astrocytes, present in white matter and distinguished by longer, fiber-like extensions

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And thats some research that has just come out within the last half a year, that we actually know now the mechanisms of these processes

Since then, amyloid and tau proteins have been sought in numerous biological media, including CSF, blood, urine, saliva, and skin, with varying degrees of success