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Moreover, the simulations confirmed that the Cagri P37 had weaker interactions with the ECDs leading to greater uncoupling of the peptide C-terminus from the ECDs (Supplementary Movie 1, Supplementary Tables 4, 5), and parallel increases in the dynamics of the peptide as it engaged with the CTR TM bundle, including F23

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Gallbladder-Related Events Cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation) occur at higher rates in semaglutide users compared to placebo