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This review highlights the recent developments in the synthesis, functional design, and biomedical application of PLGA nanocarriers in CRC treatment, emphasizing their role in overcoming key challenges such as chemoresistance and off-target toxicity

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The function of CYP3A4 and p-gp as a barrier for drug absorption [219,220,221] has been supported by in silico modelling [222,223,224,225] and in vitro experiments [226, 227]

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Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature