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In rodents, activation of AMPA receptors by the KET metabolite (2R,6R)-hydroxynorketamine has initially been thought essential to replicate KET antidepressant effects while administration of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX), an AMPA receptor antagonist, blocks KET effects (Zanos et al., 2016)

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By restoring proper levels of B12 these symptoms usually improve

[595] In section III.G.7.c.(2).(d) of the CY 2025 PFS proposed rule we discussed our proposals related to modifying these provisions

T12M mean = 21.1 9.3 mol/L