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Subsequently, we performed a comprehensive clustering analysis of 93 samples from the GSE9106 data set

1 Past investigations of cell senescence have focused on its role in tumor suppression, cell cycle arrest, tissue repair, and DNA replicative stress/damage response

Prior to glycolysis, galactose is transformed into glucose-6-phosphate

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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture