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In the process of sperm selection (e.g., density gradient centrifugation), PDEVs can protect the integrity of sperm membranes, and OFI-EVs from cactus fruits contain plant sphingolipid components that may reduce cryo-recovery damage by stabilizing sperm membrane structure (Valentino et al., 2024), Sesame-derived extracellular vesicles (SAEVs) may also improve fertilization rates by regulating calcium ion channels to promote sperm capacitation (Zhao et al., 2025)

306 After quercetin treatment, ER and PI3K/Akt/mTOR signaling were downregulated, concurrently with the inhibition of CD44 + /CD24 viability and clone formation, implied quercetin targeted cancer stem cells to promote tumor eradication