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This may include growth hormone and IGF-1 production, skin cell proliferation, and muscle tissue growth

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Dopamine also functions as a paracrine (cell-to-cell) hormone in other parts of the body

Given the essential role of astrocytes in clearing and detoxifying many substances and the changes in astrocyte functions that such substances can evoke, it is interesting to consider (and worthy of more extensive investigation) that chronic exposure to trace amounts of such substances might act as risk factors and comorbidities in a variety of CNS neurodegenerative conditions