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The defective mitochondrial biogenesis is driven by the upregulation of the Parkin substrate PARIS and the subsequent downregulation of PGC-1 (Ge et al., 2020)

134 YangB.LiuJ.ChangX.LinD

10.6091/ibj.13362.2014 245 SolimanM

Supporting this idea is the fact that several incretin agonists like semaglutide and liraglutide have been linked to improvements in heart health among people with diabetes