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While there are no extensive RCTs data that discredit the association of irAEs with good clinical outcomes, a landmark analysis of a retrospective review of only 97 patients showed no difference in OS at 3 months in patients on single-agent ICI, even though the incidence of irAEs was associated with an OS (24.3 versus 5.3 months

These abnormalities are underpinned by the dysregulated formation and function of epithelial cells [104]

Alexandra Naba Author profile: Nature Reviews Molecular Cell Biology author profile (Alexandra Naba) Alexandra Naba is a research author whose work on the extracellular matrix (ECM) informs broader discussions of cellular environments, matrix composition, and structural frameworks that can intersect with laboratory peptide research contexts

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(3) M Alba, D Fintini, A Sagazio, B Lawrence, JP Castaigne, L A Frohman, R Salvatori (2006) Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse American Journal of Physiology