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It has been shown to upregulate genes associated with DNA repair and antioxidant defense while simultaneously downregulating genes linked to inflammation and cellular senescence (aging)

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By targeting the stubborn, pro-inflammatory senescent cells that accumulate with age, FOXO4-DRI offers the possibility of clearing the cellular garbage that impedes regeneration, contributes to chronic disease and ageing decline

81 Notably, Wnt5a, a common nonclassical Wnt pathway activator, after secretion by fibroblasts, activates the classic Wnt signalling pathway in AT2 cells and inhibits the transdifferentiation of AXIN2 + AT2 cells with stem cell activity into AT1 cells, thus maintaining the dryness of AT2 cells