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Figure 2 Limitations and future prospects Despite its microbial richness, propolis intervention did not alter plasma levels of uremic toxins such as indole-3 acetic acid, p-cresyl sulfate, and indoxyl sulfate, nor did it significantly change gut microbiota composition ( Bifidobacterium and Blautia spp.) and reduced eGFR, further studies are needed to clarify their impact on kidney function ( Probiotics also showed limited efficacy

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Patients receiving telitacicept, particularly at a dosage of 240 mg weekly, experienced a substantial reduction in proteinuria, with a mean decrease of 49% from baseline, which was statistically significant compared to the placebo group (P = 0.013)