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Commun Biol 8 , 1516 (2025)

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Effects of NO Modulation on Cardiac Arrhythmias in the Rat Isolated Heart

Defective fission-fusion dynamics, impaired mitophagic clearance, suppressed biogenesis, and disrupted proteostasis converge to produce bioenergetic failure, pathological ROS overproduction, calcium dyshomeostasis, and resistance to apoptosis, thereby transforming mitochondria from cellular powerhouses into drivers of lesion persistence and inflammation