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Concurrently, there is a downregulation in the expression of components of voltage-gated potassium channels, which normally regulate neuronal excitability, repolarization, and frequency of action potentials

Am J Emerg Med

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Specifically, tendons are highly collagenous, so anyone who's straining their tendons on a regular basis (with intense exercise or heavy lifting) should make collagen-synthesis support a priority

Secondly, dietary indoles can effectively lower TMAO levels and inhibit FMO3 activity, however, their lack of specificity arises from their role as potent 5-HT agonists, with the ability to cross the blood-brain barrier and potentially induce adverse psychological effects (Cashman et al., 1999