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In the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, curcumin intervention attenuated the reduction of tyrosine hydroxylase levels in both substantia nigra pars compacta and striatum, inhibited AIM2-mediated pyroptosis and caspase-1 activation, and decreased pro-inflammatory factors and inflammatory responses in the intestinal tract

Immunoblotting of ER-tag immunoprecipitates (ER-IP) showed robust enrichment of ER proteins with minimal contamination from other compartments (Fig

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