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Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist

Front Neurosci (2017) 11:490:490

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2.2.2 Molecular changes In the CNS, quiescent microglia, in response to proinflammatory cytokines from pathogen debris and damaged cells, show an activated phenotype expressing proinflammatory factors such as IL-6, TNF-, IL-1, NO and proteases, which have negative effects on neurodegenerative processes (Liddelow and Barres, 2017)