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Because they are naturally occurring sequences in the human body, they are generally well-tolerated with minimal documented toxicity

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However, not all patients with severe cyanide poisoning given the sodium nitrite/sodium thiosulfate antidote combination have survived (Chen & Rose, 1952

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Deficiency in Vitamin B12, for instance, disturbs homocysteine levels, impairs DNA replication, and slows epidermal turnover