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Systemic inflammation Inflammation within the CNS is commonly associated with brain microvasculature injuries and dysfunction, as previously described

A growing body of research suggests that the glioma immunosuppressive microenvironment (GIME) contributes to the poor efficacy of glioma immunotherapy (6163)

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Nintedanib, a multi-target receptor tyrosine kinase inhibitor, targets VEGFR , PDGF , FGFR , FMS-associated tyrosine kinase 3 , and SRC family kinases, thus increasing the efficacy of single-target VEGF drugs 84 ( Table 1 )